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Confinia Cephalalgica, a peer-reviewed open access journal, focuses on publishing articles related to various aspects of headache medicine, including genetics, pathophysiology, diagnosis, imaging, management, epidemiology, pharmacology, and treatment. It covers both primary and secondary headaches, as well as other facial pains and their connections with systemic diseases. The journal aims to stay updated with rapidly evolving areas of medicine, such as digital health, gender medicine, and artificial intelligence, as applied to the field of headache medicine. 
Confinia Cephalalgica is the official journal of the Italian Society for the Study of Headaches (SISC) with the overarching goal to serve as a forum for scientists and clinicians dedicated to headache medicine.

New Articles

  • Anti-CGRP monoclonal antibodies and migraine with aura: a narrative review

    Danilo Antonio Montisano, Marcella De Luca, Sara Giannoni, Giada Giuliani, Marilena Marcosano, Antonio Munafò, Daniele Pala, Federica Pes, Marina Romozzi, Gabriele Sebastianelli
    https://doi.org/10.4081/cc.2025.15789
    50
    PDF: 50

  • Intraparenchymal cerebral hemorrhage in a patient undergoing treatment with galcanezumab: the importance of adequate blood pressure control

    Yan Tereshko, Antonio Taglialatela, Iacopo Cancelli, Enrico Belgrado, Lorenzo Verriello, Giovanni Merlino, Mariarosaria Valente
    https://doi.org/10.4081/cc.2025.15786
    37
    PDF: 17

  • Exploring social cognition in migraine: a narrative review

    Virginia Batti, Elisa Maria Piella, Aurora Cermelli, Chiara Lombardo, Fausto Roveta, Innocenzo Rainero, Elisa Rubino
    https://doi.org/10.4081/cc.2025.15787
    269
    PDF: 86

  • Alexithymia profile across migraine subtypes: a cross-sectional study

    Marina Romozzi, Sonia Di Tella, Catello Vollono, Chiara Abagnale, Gabriele Sebastianelli, Giuliana Ricotta, Cherubino Di Lorenzo, Luigi Francesco Iannone, Costanza Sottani, Raffaele Turano, Isabella Anzuino, Maria Caterina Silveri, Paolo Calabresi, Francesco Casillo, Gianluca Coppola
    https://doi.org/10.4081/cc.2025.15781
    333
    PDF: 116

  • Migraine management in adolescents: treatment requires a multimodal approach

    Licia Grazzi, Paul B. Rizzoli, Danilo Antonio Montisano, Alberto Raggi
    https://doi.org/10.4081/cc.2025.15782
    332
    PDF: 125

  • Effects of botulinum toxin type A in a migraine-specific animal model

    Chiara Demartini, Rosaria Greco, Sara Facchetti, Miriam Francavilla, Anna Maria Zanaboni, Daniele Martinelli, Cristina Tassorelli
    https://doi.org/10.4081/cc.2025.15779
    730
    PDF: 148

  • Exploring the cortical effect of monoclonal antibodies against CGRP ligand: a pilot study of the cortical silent period in migraine

    Gabriele Sebastianelli, Giulia Rosaria Melis, Chiara Abagnale, Francesco Casillo, Cherubino Di Lorenzo, Mariano Serrao, Gianluca Coppola
    https://doi.org/10.4081/cc.2025.15778
    829
    PDF: 155

  • Kinetic oscillation stimulation for the preventive treatment of refractory chronic migraine: a case series

    Giorgio Liaci, Claudia Altamura, Nicoletta Brunelli, Alessandro Alesina, Luisa Fofi, Maria Pia Prudenzano, Fabrizio Vernieri
    https://doi.org/10.4081/cc.2024.15776
    750
    PDF: 171
  • Image source: wayhomestudio on Freepik

    Sex and gender differences in the epidemiology, clinical features, and pathophysiology of trigeminal autonomic cephalalgias

    Selene Attorre, Andrea Burgalassi, Giulia Vigani, Francesco De Cesaris, Marina Romozzi, Luigi Francesco Iannone
    https://doi.org/10.4081/cc.2024.15775
    1715
    PDF: 266

  • Efficacy and safety of greater occipital nerve block with a small volume of lidocaine and methylprednisolone in tertiary headache center

    Chiara Rosignoli, Agnese Onofri, Federico De Santis, Simona Sacco, Raffaele Ornello
    https://doi.org/10.4081/cc.2024.15770
    3809
    PDF: 334

  • Cortical excitability in patients with migraine with aura and depressive symptoms: a visual evoked potentials study

    Francesco Casillo, Chiara Abagnale, Gabriele Sebastianelli, Antonio Di Renzo, Vincenzo Parisi, Ettore Cioffi, Mariano Serrao, Cherubino Di Lorenzo
    https://doi.org/10.4081/cc.2024.15764
    2997
    PDF: 436

  • Prospective evaluation of aura during anti-calcitonin gene-related peptide monoclonal antibody therapy after 52 weeks of treatment

    Marina Romozzi, Andrea Burgalassi, Catello Vollono, Maria Albanese, Giulia Vigani, Francesco De Cesaris, Alberto Chiarugi, Paolo Calabresi, Luigi Francesco Iannone
    https://doi.org/10.4081/cc.2024.15762
    3417
    PDF: 430

  • Anti-CGRP monoclonal antibodies improve cognitive function in patients affected by chronic migraine complicated with medication overuse-headache

    Simona Guerzoni, Flavia Lo Castro, Carlo Baraldi, Daria Brovia, Fabio Tascedda, Veronica Rivi, Luca Pani
    https://doi.org/10.4081/cc.2024.15760
    2918
    PDF: 524

  • ID-Migraine test for pediatric population: preliminary results from the Italian validation

    Ilaria Frattale, Laura Papetti, Fabiana Ursitti, Giorgia Sforza, Gabriele Monte, Luigi Mazzone, Massimiliano Valeriani
    https://doi.org/10.4081/cc.2024.15761
    2670
    PDF: 408

  • Normative values of the nociceptive blink reflex habituation

    Michele Corrado, Elena Mazzotta, Gloria Vaghi, Francescantonio Cammarota, Federico Bighiani, Alessandro Antoniazzi, Daniele Martinelli, Maria Magdalena Pocora, Luca Martinis, Valentina Grillo, Sara Bottiroli, Armando Perrotta, Giuseppe Cosentino, Grazia Sances, Cristina Tassorelli, Roberto De Icco
    https://doi.org/10.4081/cc.2024.15730
    2183
    PDF: 325
    SUPPLEMENTARY MATERIAL: 204