Headache and pain research
Vol. 32 No. 3 (2022)

Unbiased research is needed for rational translation of essential oils in clinic

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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 6 December 2022
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bias, clinical aromatherapy, bergamot essential oil, NanoBEO, severe dementia, pain, agitation, I-MOBID-2, CONSORT

Authors

Damiana Scuteri
damiana.scuteri@unical.it
Laura Rombolà
Luigi Antonio Morrone
Shinobu Sakurada
Tsukasa Sakurada
Paolo Tonin
Giorgio Sandrini
Giacinto Bagetta
a:1:{s:5:"en_US";s:22:"University of Calabria";}, Italy.
Maria Tiziana Corasaniti

The use of complementary and integrative therapies is steadily growing though the quality of clinic evidence for the use of essential oils is hampered by several methodological biases. Lack of rigorous methodology in clinical studies with aromatherapy originates poor quality evidence and scientific response to overcome the biases of this field of research is needed. Accordingly, here we display a possible step-by-step preclinical-to-clinical pathway, that was followed for the essential oil of bergamot (BEO), to overcome typical biases of research in the field of essential oils, in order to provide good quality body of evidence. 

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1.
Unbiased research is needed for rational translation of essential oils in clinic. Confinia Cephalal [Internet]. 2022 Dec. 6 [cited 2026 Feb. 2];32(3):e2022027. Available from: https://www.confiniacephalalgica.com/site/article/view/13793